It appears you can only make changes to the HKCU hive by running it as User. However, where the user does not have rights to the relevant hive in HKLM, it is necessary to run the edit as System.

In Zen 4.5 (which I've used up till now) it was possible to change both where required. Is the only way to do this in ZCM to have two Actions, running one as User and one as System? This does not seem like an improvement.

Also using the Registry Edit is about 10 times slower than with Zen 4.5, sigh.