I've seen that we have this issue also on 10.2.2.
The problem is that when you right click on the Z icon i get the ballon message "The zenworks service does not appears to be running. So i can't get any properties.

This issue is not on every start so it's hard to find where its coming from.

I've no virusscan installed on this workstations so that is not the problem.

I know this issue was also on 10.x versions, but its still coming.

Someone that also have this problem?, maybe a solution :S