I'm having an issue with one of our Active Directory business units
where they are prompted to log in to ZENworks every time they log in to
the network.

ZENworks logins appear to succeed, all user associated bundles and
policies show up and the ZENworks properties show the domain\user logged
in, but the registry subkeys (CachedUserZenNames, RealmName and
ZenUsername) under HKLM\SOFTWARE\Novell\Zenworks\ZenLgn\History never
get created. Users are bog-standard Users accounts.

Registry permissions issue perhaps? Are those subfolders created using
the users' privileges or SYSTEM via the agent?