Has anyone else seen this?

Where a domain you're system sends mail to regularly suddenly comes up
with all 450.
Check if they've changed their MX or matching A records. I just
encountered an issue where the DNS change had propagated just fine. I
could do NSLookups on the host server to get the correct/new entries,
but GWIA didn't want to see it until after a restart.
This GWIA (8.02hp2 on SLES10sp3 -64bit) had gone more than 10 times the
TTL without refreshing for a connection it.

Andy Konecny
KonecnyConsulting.ca in Toronto
Andy's Profile: http://forums.novell.com/member.php?userid=75037