I just upgraded to 2017 and as I began testing the new 2017 agent ran into an issue deploying it from System Update to Windows 10 devices.

They all fail with the error:
The update was aborted because a pre-requisite check failed: This update cannot continue as Client Self Defense is enabled for ZENworks Adaptive Agent. Please disable it.

I have confirmed turning off the agent self defense allows the update to proceed but obviously don't want to turn it off across the board or have to touch each windows 10 device manually. Has anyone else run into this? Is this a known issue?