With Office 2016 installed on a Win 10 64-bit Pro machines with all latest patches installed and GW 2014 R2 v14.2.2 client
When user tries to click File, Share, and Word Document or .pdf, it says "Word couldn't send mail because of MAPI failure.
Unspecified error.".

Does anyone know how to try to fix this?

Brand NEW install of Windows 10 Pro, 1709 Build 248 - Fully patched
Microsoft Office Home and Business (note there is NO option to leave out Outlook!)
GroupWise gw14.2.2-129737-1214 client
NO Anti-Virus (just defender)

>> opened a SR on the 15th - still no solution !
Just to clarify - GroupWise is the Default Mail Client
Clicking a link with mailto does open GroupWise (ie. not Outlook)
Windows 10 Pro 1709 build 248
MS Office 2016 Home & Business - [this is NOT Office 365]
Tried the suggested gw14.2.2-129737-1214 client

Note: with Dozens of emails to / from Novell support - no solution yet!

I have actually Re-Installed Windows 10, Office 2016 Home & Business and GroupWise client at least 4 time !